Wednesday, April 3, 2013

U.N. approves first-ever global arms trade treaty

By Louis Charbonneau

UNITED NATIONS (Reuters) - The 193-nation U.N. General Assembly overwhelmingly approved on Tuesday the first-ever treaty on global arms trade that seeks to regulate the $70 billion international business in conventional arms ranging from light weapons to battle tanks and warships.

There were 154 votes in favor, 3 against and 23 abstentions.

Iran, Syria and North Korea last week prevented a treaty-drafting conference at U.N. headquarters from reaching the required consensus to adopt the treaty. That left delegations that support it no choice but to turn to a General Assembly vote to adopt it.

The Iranian, Syrian and North Korean delegations cast the sole votes against the treaty on Tuesday.

Iran, which is under a U.N. arms embargo over its nuclear program, is eager to ensure its arms imports and exports are not curtailed, diplomats said. Syria's government is embroiled in a two-year civil war and relies on Russian and Iranian weapons, they added.

North Korea is also under a U.N. arms embargo due to its nuclear weapons and missile programs.

The treaty will be open for signature on June 3 and will enter into force 90 days after the 50th signatory ratifies it.

Major arms producers China and Russia joined Cuba, Venezuela, Bolivia, Nicaragua and other countries in abstaining. A number of countries, led by India, which also abstained, complained the treaty favored exporting over importing states.

The United States, the world's No. 1 arms exporter, voted in favor of the treaty despite fierce opposition from the National Rifle Association, a powerful U.S. pro-gun lobbying group.

U.S. Secretary of State John Kerry said in a statement that the U.N. adopted "a strong, effective and implementable Arms Trade Treaty (ATT) that can strengthen global security while protecting the sovereign right of states to conduct legitimate arms trade."

"Nothing in this treaty could ever infringe on the rights of American citizens under our domestic law or the Constitution, including the Second Amendment," he added, referring to the U.S. constitutional amendment that guarantees the right to bear arms.

The NRA opposes the treaty and has vowed to fight to prevent its ratification by the U.S. Senate when it reaches Washington. The NRA says the treaty will undermine domestic gun rights, a view the U.S. government has strongly rejected.

NRA FAILURE?

Syrian U.N. Ambassador Bashar Ja'afari repeated that his government opposes the arms trade treaty because it does not ban the sale of weapons to non-state actors and "terrorists" like those allegedly active in Syria. The civil war there has claimed at least 70,000 lives, according to U.N. estimates.

Syria routinely refers to rebels trying to oust President Bashar al-Assad as "terrorists" backed by foreign governments.

The treaty does not ban transfers to armed groups but says all arms transfers should be subjected to rigorous risk and human rights assessments first.

British Prime Minister David Cameron hailed the vote as a "landmark agreement that will save lives and ease the immense human suffering caused by armed conflict around the world."

Mexico issued a statement on behalf of 98 U.N. member states saying "an effective implementation of this treaty will make a real difference for the people of the world."

U.N. member states began meeting on March 18 in a final push to end years of discussions and hammer out a binding international treaty to end the lack of regulation over cross-border conventional arms sales.

Arms control activists and rights groups have said a treaty was needed to halt the uncontrolled flow of arms and ammunition that they say fuels wars, atrocities and rights abuses.

The ATT aims to set standards for all cross-border transfers of conventional weapons. It also would create binding requirements for states to review all cross-border arms contracts to ensure that arms will not be used in human rights abuses, terrorism or violations of humanitarian law.

"The agreement of the Arms Trade Treaty sends a clear message to arms dealers who supply warlords and dictators that their time is up," said Anna Macdonald of the global development group Oxfam. "They will no longer be able to operate and arm themselves with impunity."

Amnesty International's Frank Jannuzi said the NRA, which claimed credit last year for persuading the United States to block the treaty in July 2012, had failed this time.

"Iran, Syria and North Korea blocked consensus at the U.N., while the NRA cynically - and ultimately unsuccessfully - tried to erode the U.S. government's support through a campaign of lies about the treaty," Jannuzi said.

The main reason the arms trade talks took place at all is that the United States - the world's biggest arms trader - reversed U.S. policy on the issue after President Barack Obama was first elected and decided in 2009 to support a treaty.

(Reporting By Louis Charbonneau; Editing by Philip Barbara and Paul Simao)

Source: http://news.yahoo.com/u-n-overwhelmingly-approves-first-ever-global-arms-155542094.html

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Tuesday, April 2, 2013

April 2 Pets: Jolie | KTLA 5

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Source: http://ktla.com/2013/04/02/april-2-pets-jolie/

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Rubio: Immigration deal still needs hashing out

Republican Sen. Marco Rubio cautioned that the bipartisan group of senators working on immigration reform legislation still has details to work out. Democrat Chuck Schumer said the group was on track.

By Philip Elliott,?Associated Press / March 31, 2013

Sen. Marco Rubio, R-Fla. on Capitol Hill in Washington on March 12. On Sunday, Rubio said the eight senators working on immigration reform legislation still had many details to work out, and cautioned against premature celebration.

Susan Walsh/AP/File

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Even with one of the largest hurdles to an immigration overhaul overcome, optimistic lawmakers on Sunday cautioned they had not finished work on a bill that would provide a path to citizenship for 11 million illegal immigrants.

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The AFL-CIO and the pro-business U.S. Chamber of Commerce reached a deal late Friday that would allow tens of thousands of low-skill workers into the country to fill jobs in construction, restaurants and hotels. Yet despite the unusual agreement between the two powerful lobbying groups, lawmakers from both parties conceded that the negotiations were not finished.

"With the agreement between business and labor, every major policy issue has been resolved," said Sen. Chuck Schumer, the New York Democrat who brokered the labor-business deal.

But it hasn't taken the form of a bill and the eight senators searching for a compromise haven't met about the potential breakthrough.

"We haven't signed off," said Sen. Lindsey Graham, R-S.C.

"There are a few details yet. But conceptually, we have an agreement between business and labor, between ourselves that has to be drafted," he added.

Yet just before lawmakers began appearing on Sunday shows, Sen.?Marco?Rubio?warned he was not ready to lend his name ? and political clout ? to such a deal without hashing out the details.

"Reports that the bipartisan group of eight senators have agreed on a legislative proposal are premature," said?Rubio, a Florida Republican who is among the lawmakers working on legislation.

Rubio, a Cuban-American who is weighing a presidential bid in 2016, is a leading figure inside his party. Lawmakers will be closely watching any deal for his approval and his skepticism about the process did little to encourage optimism.

Rubio, who is the group's emissary to conservatives, called the agreement "a starting point" but said 92 senators from 43 states haven't yet been involved in the process.

The detente between the nation's leading labor federation and the powerful business lobbying group still needs senators' approval, including a nod from Sen. John McCain, the Arizona Republican whose previous efforts came up short.

"I think we're on track. But as Sen.?Rubio?correctly says, we have said we will not come to final agreement till we look at all of the legislative language and he's correctly pointing out that that language hasn't been fully drafted," Schumer said.

Sen. Jeff Flake, R-Ariz., also noted the significance of the truce between labor and business but added that this wasn't yet complete.

"That doesn't mean we've crossed every 'i' or dotted every 't,' or vice versa," said Flake, who is among the eight lawmakers working on the deal.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/NQLoboKklXQ/Rubio-Immigration-deal-still-needs-hashing-out

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Monday, April 1, 2013

Newly approved blood thinner may increase susceptibility to some viral infections

Apr. 1, 2013 ? A study led by researchers at the University of North Carolina indicates that a newly approved blood thinner that blocks a key component of the human blood clotting system may increase the risk and severity of certain viral infections, including flu and myocarditis, a viral infection of the heart and a significant cause of sudden death in children and young adults.

For the past 50 years, people with the heartbeat irregularity, atrial fibrillation, and others at increased risk for forming potentially life-threatening blood clots have been given the anticoagulant drug warfarin. Recently, the U.S. Food and Drug Administration approved the use of the blood-thinner Dabigatran etexilate (called Pradaxa?) for atrial fibrillation patients. The drug inhibits thrombin, the body's central coagulation activator of the blood clotting system.

In blocking thrombin activity, the drug disturbs the protease cascade of molecular events that normally occurs in coagulation. While clot formation is reduced, the new study shows it may also cause an unintended consequence. "Our findings show that blocking thrombin reduces the innate immune response to viral infection," says study senior author Nigel Mackman, PhD, the John C. Parker Distinguished Professor of Medicine in the division of hematology and director of the UNC McAllister Heart Institute. "The use of the new generation of blood thinners might increase the risk and severity of flu and myocarditis."

A report of the research appears in the March 2013 issue of The Journal of Clinical Investigation.

Mackman points out that viral infections such as dengue fever trigger activation of the coagulation system but it was considered a bad thing. He says studies on bacterial infections have found that the last product of the "clotting cascade" (the process that occurs in blood clot formation) -- fibrin -- helps activate immune cell macrophages that boosts the immune system.

"But it seems that the antiviral mechanism of the clotting system is not via fibrin but rather via thrombin; namely, its activation of protease activated receptor proteins such as PAR-1," says Mackman. "The new study was aimed at finding out if PAR-1 plays any role in virus infections, a question of importance to the use of Pradaxa? and the development of antithrombotic drugs that target PAR-1 on platelets."

To find the answer, Mackman and colleagues used mice in which the PAR-1 gene is deleted and subjected then to infection with a virus that causes myocarditis. They found that loss of PAR-1 mediated signaling after infection with the cardiotrophic virus resulted in increased viral buildup in the heart, cardiac injury and, later, increased impairment of heart function.

Moreover, the absence of PAR-1 signaling was associated with a slower response to the virus of the innate immune soon after viral infection. The innate immune system provides early defense against disease causing organisms. The defense is almost immediate.

The researchers treated normal mice with Pradaxa?. They showed that thrombin inhibition increased cardiac virus load and cardiac injury after viral infection in a similar manner to a deficiency of PAR-1. In addition, they infected the PAR-1 deficient mice with influenza A and found that PAR-1 signaling was important in controlling the virus load in the lung in the early phase after infection. These results suggest that thrombin and PAR-1 mediate important early antiviral signals after infection.

"Pradaxa? inhibits clot formation by reducing fibrin deposition and platelet aggregation." said Mackman. "Importantly, Pradaxa? might not only facilitate significant lifesaving effects in reducing cardiac death but may also interfere with other processes in the body.

"The results we generated were completely unexpected and in fact our hypothesis was that PAR-1 deficient mice would be protected from viral myocarditis because they would have reduced inflammation," Mackman added. "We are now determining if the traditional long term anticoagulant warfarin has the same effect on viral infection or is this specific to the new blood thinner."

The majority of the study was a collaboration between the Mackman group at UNC and the Charit? -- Universit?tsmedizin in Berlin, Germany, and other groups at UNC, including at the Gillings School of Global Public Health, and across the USA.

The first-author is Silvio Antoniak, PhD, a postdoctoral researcher in Mackman's lab. Other co-authors from Mackman's lab were A. Phillip Owens III, PhD; Martin Baumnacke, MD; and Julie C. Williams, PhD.

The study was supported by the Myocarditis Foundation through a research grant to Silvio Antoniak. Additional funds were provided by the National Heart, Lung and Blood Institute (NHLBI), a component of the National Institutes of Health.

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Story Source:

The above story is reprinted from materials provided by University of North Carolina Health Care.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Silvio Antoniak, A. Phillip Owens, Martin Baunacke, Julie C. Williams, Rebecca D. Lee, Alice Weith?user, Patricia A. Sheridan, Ronny Malz, James P. Luyendyk, Denise A. Esserman, JoAnn Trejo, Daniel Kirchhofer, Burns C. Blaxall, Rafal Pawlinski, Melinda A. Beck, Ursula Rauch, Nigel Mackman. PAR-1 contributes to the innate immune response during viral infection. Journal of Clinical Investigation, 2013; 123 (3): 1310 DOI: 10.1172/JCI66125

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/ANitGbFwha4/130401132058.htm

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500 Startups-Backed Food Delivery Startup Chewse Raises $1 Million From Chris Sacca And Others

chewse logoThere are all sorts of startups looking to make life easier, including a whole bunch trying to make ordering lunch a no-brainer. Chewse is the newest entrant into the food delivery game, as it seeks to provide office admins a new, easy way to get lunch catered. To do so, the company has raised $1 million in seed funding from a group of investors that include Chris Sacca and 500 Startups.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/H21lIFZ_3eE/

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Exxon cleans up Arkansas oil spill; Keystone plan assailed

(Reuters) - Exxon Mobil on Sunday continued cleanup of a pipeline spill that loosed thousands of barrels of heavy Canadian crude in Arkansas as opponents of oil sands development latched on to the incident to attack plans to build the Keystone XL line.

Exxon's Pegasus pipeline, which can carry more than 90,000 barrels per day (bpd) of crude from Pakota, Illinois to Nederland, Texas, was shut after the leak was discovered late Friday afternoon in a subdivision near the town of Mayflower. The leak forced the evacuation of 22 homes.

The company did not have an estimate for the restarting of the pipeline, which was carrying Canadian Wabasca Heavy crude at the time of the leak. An oil spill of more than 1,000 barrels into a Wisconsin field from an Enbridge (Toronto: ENB.TO - news) pipeline last summer kept that line shuttered for around 11 days.

The Arkansas spill drew fast reaction from opponents of the 800,000 bpd Keystone XL pipeline, which would carry heavy crude from Canada's tar sands to the U.S. Gulf Coast refining centre.

Environmentalists have expressed concerns about the impact of developing the oil sands and say the crude is more corrosive to pipelines than conventional oil. On Wednesday, a train carrying Canadian crude derailed in Minnesota, spilling 15,000 gallons of oil.

"Whether it's the proposed Keystone XL pipeline, or ... (the) mess in Arkansas, Americans are realizing that transporting large amounts of this corrosive and polluting fuel is a bad deal for American taxpayers and for our environment," said Representative Ed Markey, a Massachusetts Democrat.

Supporters of Keystone XL and oil sands development say the vast Canadian reserves can help drive down fuel costs in the United States. A report from the Canadian Energy Pipeline Association, put together by oil and gas consultancy Penspen, argued diluted bitumen is no more corrosive than other heavy crude.

CLEANUP

Exxon said that by 3 a.m. Saturday there was no additional oil spilling from the pipeline and that trucks had been brought in to assist with the cleanup. Images from local media showed crude oil snaking along a suburban street.

Officials from the U.S. Environmental Protection Agency and the Department of Transportation's Pipeline and Hazardous Materials Safety Administration were deployed to the scene.

"Cleanup efforts are progressing 24 hours a day," said Exxon spokesman Alan Jeffers, who added the oil had not leaked into nearby Lake Conway.

"We were very fortunate that the local responders made sure the oil did not enter the water."

(Reporting by Matthew Robinson in New York and Timothy Gardner in Washington; Editing by Steve Orlofsky)

Source: http://news.yahoo.com/exxon-shuts-oil-pipeline-major-005905765.html

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Versatile music producer Phil Ramone dies at 79: report

LOS ANGELES (Reuters) - Phil Ramone, a versatile music producer who won 14 Grammy Awards and worked with a glittering roster of stars like Billy Joel, Tony Bennett, Ray Charles and Paul Simon, died in Manhattan on Saturday, the New York Times reported. He was 79.

Ramone's son, Matthew, confirmed the death to the newspaper but did not release a cause.

Born in South Africa, Ramone was raised in Brooklyn, New York. In the late 1950s he co-founded an independent studio called A&R Recording in New York.

His first Grammy was for his sound engineering on the 1964 jazz-bossa nova album "Getz/Gilberto" by Stan Getz and Joao Gilberto.

He went on to win a total of 14 Grammy Awards, including album of the year honors for producing Paul Simon's top-selling 1975 release "Still Crazy After All These Years" and Ray Charles' 2004 duets album "Genius Loves Company."

Tony Bennett, whose series of "duets" albums were produced by Ramone, said in a statement that Ramone was a "very gifted musician and producer."

"It was a joy to have him work with me in the recording studio on so many projects, as he had a wonderful sense of humor and a deep love of music," Bennett said.

Neil Portnow, president and chief executive of the National Academy of Recording Arts and Sciences, said in a statement Ramone had made "countless significant contributions" to the music industry.

"Our industry has lost an immense talent and a true visionary and genius, and The Academy has lost a very dear and close friend," he said. "Everyone who encountered Phil came away a better person for it, professionally or personally."

Ramone was an early advocate of the compact disc. He played a key role in the introduction of the CD when the 1978 Billy Joel album "52nd Street," which Ramone had produced, was re-released in 1982 as the first commercially available album on CD.

He showed a passion for all forms of entertainment, applying his musical talents to projects in film, theater and television. He worked as a music supervisor on the popular 1983 film "Flashdance" and the 1985 dance movie "White Nights."

The Times reported that, although some media sources had said he was 72, public records and his family confirmed that Ramone was 79.

Ramone was not associated with the punk band The Ramones, whose members all adopted pseudonyms using the surname Ramone.

(Reporting by Alex Dobuzinskis; Editing by Tim Gaynor and Philip Barbara)

Source: http://news.yahoo.com/versatile-music-producer-phil-ramone-dies-79-report-234022565.html

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