Tuesday, April 2, 2013

Rubio: Immigration deal still needs hashing out

Republican Sen. Marco Rubio cautioned that the bipartisan group of senators working on immigration reform legislation still has details to work out. Democrat Chuck Schumer said the group was on track.

By Philip Elliott,?Associated Press / March 31, 2013

Sen. Marco Rubio, R-Fla. on Capitol Hill in Washington on March 12. On Sunday, Rubio said the eight senators working on immigration reform legislation still had many details to work out, and cautioned against premature celebration.

Susan Walsh/AP/File

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Even with one of the largest hurdles to an immigration overhaul overcome, optimistic lawmakers on Sunday cautioned they had not finished work on a bill that would provide a path to citizenship for 11 million illegal immigrants.

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The AFL-CIO and the pro-business U.S. Chamber of Commerce reached a deal late Friday that would allow tens of thousands of low-skill workers into the country to fill jobs in construction, restaurants and hotels. Yet despite the unusual agreement between the two powerful lobbying groups, lawmakers from both parties conceded that the negotiations were not finished.

"With the agreement between business and labor, every major policy issue has been resolved," said Sen. Chuck Schumer, the New York Democrat who brokered the labor-business deal.

But it hasn't taken the form of a bill and the eight senators searching for a compromise haven't met about the potential breakthrough.

"We haven't signed off," said Sen. Lindsey Graham, R-S.C.

"There are a few details yet. But conceptually, we have an agreement between business and labor, between ourselves that has to be drafted," he added.

Yet just before lawmakers began appearing on Sunday shows, Sen.?Marco?Rubio?warned he was not ready to lend his name ? and political clout ? to such a deal without hashing out the details.

"Reports that the bipartisan group of eight senators have agreed on a legislative proposal are premature," said?Rubio, a Florida Republican who is among the lawmakers working on legislation.

Rubio, a Cuban-American who is weighing a presidential bid in 2016, is a leading figure inside his party. Lawmakers will be closely watching any deal for his approval and his skepticism about the process did little to encourage optimism.

Rubio, who is the group's emissary to conservatives, called the agreement "a starting point" but said 92 senators from 43 states haven't yet been involved in the process.

The detente between the nation's leading labor federation and the powerful business lobbying group still needs senators' approval, including a nod from Sen. John McCain, the Arizona Republican whose previous efforts came up short.

"I think we're on track. But as Sen.?Rubio?correctly says, we have said we will not come to final agreement till we look at all of the legislative language and he's correctly pointing out that that language hasn't been fully drafted," Schumer said.

Sen. Jeff Flake, R-Ariz., also noted the significance of the truce between labor and business but added that this wasn't yet complete.

"That doesn't mean we've crossed every 'i' or dotted every 't,' or vice versa," said Flake, who is among the eight lawmakers working on the deal.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/NQLoboKklXQ/Rubio-Immigration-deal-still-needs-hashing-out

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Monday, April 1, 2013

Newly approved blood thinner may increase susceptibility to some viral infections

Apr. 1, 2013 ? A study led by researchers at the University of North Carolina indicates that a newly approved blood thinner that blocks a key component of the human blood clotting system may increase the risk and severity of certain viral infections, including flu and myocarditis, a viral infection of the heart and a significant cause of sudden death in children and young adults.

For the past 50 years, people with the heartbeat irregularity, atrial fibrillation, and others at increased risk for forming potentially life-threatening blood clots have been given the anticoagulant drug warfarin. Recently, the U.S. Food and Drug Administration approved the use of the blood-thinner Dabigatran etexilate (called Pradaxa?) for atrial fibrillation patients. The drug inhibits thrombin, the body's central coagulation activator of the blood clotting system.

In blocking thrombin activity, the drug disturbs the protease cascade of molecular events that normally occurs in coagulation. While clot formation is reduced, the new study shows it may also cause an unintended consequence. "Our findings show that blocking thrombin reduces the innate immune response to viral infection," says study senior author Nigel Mackman, PhD, the John C. Parker Distinguished Professor of Medicine in the division of hematology and director of the UNC McAllister Heart Institute. "The use of the new generation of blood thinners might increase the risk and severity of flu and myocarditis."

A report of the research appears in the March 2013 issue of The Journal of Clinical Investigation.

Mackman points out that viral infections such as dengue fever trigger activation of the coagulation system but it was considered a bad thing. He says studies on bacterial infections have found that the last product of the "clotting cascade" (the process that occurs in blood clot formation) -- fibrin -- helps activate immune cell macrophages that boosts the immune system.

"But it seems that the antiviral mechanism of the clotting system is not via fibrin but rather via thrombin; namely, its activation of protease activated receptor proteins such as PAR-1," says Mackman. "The new study was aimed at finding out if PAR-1 plays any role in virus infections, a question of importance to the use of Pradaxa? and the development of antithrombotic drugs that target PAR-1 on platelets."

To find the answer, Mackman and colleagues used mice in which the PAR-1 gene is deleted and subjected then to infection with a virus that causes myocarditis. They found that loss of PAR-1 mediated signaling after infection with the cardiotrophic virus resulted in increased viral buildup in the heart, cardiac injury and, later, increased impairment of heart function.

Moreover, the absence of PAR-1 signaling was associated with a slower response to the virus of the innate immune soon after viral infection. The innate immune system provides early defense against disease causing organisms. The defense is almost immediate.

The researchers treated normal mice with Pradaxa?. They showed that thrombin inhibition increased cardiac virus load and cardiac injury after viral infection in a similar manner to a deficiency of PAR-1. In addition, they infected the PAR-1 deficient mice with influenza A and found that PAR-1 signaling was important in controlling the virus load in the lung in the early phase after infection. These results suggest that thrombin and PAR-1 mediate important early antiviral signals after infection.

"Pradaxa? inhibits clot formation by reducing fibrin deposition and platelet aggregation." said Mackman. "Importantly, Pradaxa? might not only facilitate significant lifesaving effects in reducing cardiac death but may also interfere with other processes in the body.

"The results we generated were completely unexpected and in fact our hypothesis was that PAR-1 deficient mice would be protected from viral myocarditis because they would have reduced inflammation," Mackman added. "We are now determining if the traditional long term anticoagulant warfarin has the same effect on viral infection or is this specific to the new blood thinner."

The majority of the study was a collaboration between the Mackman group at UNC and the Charit? -- Universit?tsmedizin in Berlin, Germany, and other groups at UNC, including at the Gillings School of Global Public Health, and across the USA.

The first-author is Silvio Antoniak, PhD, a postdoctoral researcher in Mackman's lab. Other co-authors from Mackman's lab were A. Phillip Owens III, PhD; Martin Baumnacke, MD; and Julie C. Williams, PhD.

The study was supported by the Myocarditis Foundation through a research grant to Silvio Antoniak. Additional funds were provided by the National Heart, Lung and Blood Institute (NHLBI), a component of the National Institutes of Health.

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Story Source:

The above story is reprinted from materials provided by University of North Carolina Health Care.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Silvio Antoniak, A. Phillip Owens, Martin Baunacke, Julie C. Williams, Rebecca D. Lee, Alice Weith?user, Patricia A. Sheridan, Ronny Malz, James P. Luyendyk, Denise A. Esserman, JoAnn Trejo, Daniel Kirchhofer, Burns C. Blaxall, Rafal Pawlinski, Melinda A. Beck, Ursula Rauch, Nigel Mackman. PAR-1 contributes to the innate immune response during viral infection. Journal of Clinical Investigation, 2013; 123 (3): 1310 DOI: 10.1172/JCI66125

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/ANitGbFwha4/130401132058.htm

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500 Startups-Backed Food Delivery Startup Chewse Raises $1 Million From Chris Sacca And Others

chewse logoThere are all sorts of startups looking to make life easier, including a whole bunch trying to make ordering lunch a no-brainer. Chewse is the newest entrant into the food delivery game, as it seeks to provide office admins a new, easy way to get lunch catered. To do so, the company has raised $1 million in seed funding from a group of investors that include Chris Sacca and 500 Startups.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/H21lIFZ_3eE/

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Exxon cleans up Arkansas oil spill; Keystone plan assailed

(Reuters) - Exxon Mobil on Sunday continued cleanup of a pipeline spill that loosed thousands of barrels of heavy Canadian crude in Arkansas as opponents of oil sands development latched on to the incident to attack plans to build the Keystone XL line.

Exxon's Pegasus pipeline, which can carry more than 90,000 barrels per day (bpd) of crude from Pakota, Illinois to Nederland, Texas, was shut after the leak was discovered late Friday afternoon in a subdivision near the town of Mayflower. The leak forced the evacuation of 22 homes.

The company did not have an estimate for the restarting of the pipeline, which was carrying Canadian Wabasca Heavy crude at the time of the leak. An oil spill of more than 1,000 barrels into a Wisconsin field from an Enbridge (Toronto: ENB.TO - news) pipeline last summer kept that line shuttered for around 11 days.

The Arkansas spill drew fast reaction from opponents of the 800,000 bpd Keystone XL pipeline, which would carry heavy crude from Canada's tar sands to the U.S. Gulf Coast refining centre.

Environmentalists have expressed concerns about the impact of developing the oil sands and say the crude is more corrosive to pipelines than conventional oil. On Wednesday, a train carrying Canadian crude derailed in Minnesota, spilling 15,000 gallons of oil.

"Whether it's the proposed Keystone XL pipeline, or ... (the) mess in Arkansas, Americans are realizing that transporting large amounts of this corrosive and polluting fuel is a bad deal for American taxpayers and for our environment," said Representative Ed Markey, a Massachusetts Democrat.

Supporters of Keystone XL and oil sands development say the vast Canadian reserves can help drive down fuel costs in the United States. A report from the Canadian Energy Pipeline Association, put together by oil and gas consultancy Penspen, argued diluted bitumen is no more corrosive than other heavy crude.

CLEANUP

Exxon said that by 3 a.m. Saturday there was no additional oil spilling from the pipeline and that trucks had been brought in to assist with the cleanup. Images from local media showed crude oil snaking along a suburban street.

Officials from the U.S. Environmental Protection Agency and the Department of Transportation's Pipeline and Hazardous Materials Safety Administration were deployed to the scene.

"Cleanup efforts are progressing 24 hours a day," said Exxon spokesman Alan Jeffers, who added the oil had not leaked into nearby Lake Conway.

"We were very fortunate that the local responders made sure the oil did not enter the water."

(Reporting by Matthew Robinson in New York and Timothy Gardner in Washington; Editing by Steve Orlofsky)

Source: http://news.yahoo.com/exxon-shuts-oil-pipeline-major-005905765.html

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Versatile music producer Phil Ramone dies at 79: report

LOS ANGELES (Reuters) - Phil Ramone, a versatile music producer who won 14 Grammy Awards and worked with a glittering roster of stars like Billy Joel, Tony Bennett, Ray Charles and Paul Simon, died in Manhattan on Saturday, the New York Times reported. He was 79.

Ramone's son, Matthew, confirmed the death to the newspaper but did not release a cause.

Born in South Africa, Ramone was raised in Brooklyn, New York. In the late 1950s he co-founded an independent studio called A&R Recording in New York.

His first Grammy was for his sound engineering on the 1964 jazz-bossa nova album "Getz/Gilberto" by Stan Getz and Joao Gilberto.

He went on to win a total of 14 Grammy Awards, including album of the year honors for producing Paul Simon's top-selling 1975 release "Still Crazy After All These Years" and Ray Charles' 2004 duets album "Genius Loves Company."

Tony Bennett, whose series of "duets" albums were produced by Ramone, said in a statement that Ramone was a "very gifted musician and producer."

"It was a joy to have him work with me in the recording studio on so many projects, as he had a wonderful sense of humor and a deep love of music," Bennett said.

Neil Portnow, president and chief executive of the National Academy of Recording Arts and Sciences, said in a statement Ramone had made "countless significant contributions" to the music industry.

"Our industry has lost an immense talent and a true visionary and genius, and The Academy has lost a very dear and close friend," he said. "Everyone who encountered Phil came away a better person for it, professionally or personally."

Ramone was an early advocate of the compact disc. He played a key role in the introduction of the CD when the 1978 Billy Joel album "52nd Street," which Ramone had produced, was re-released in 1982 as the first commercially available album on CD.

He showed a passion for all forms of entertainment, applying his musical talents to projects in film, theater and television. He worked as a music supervisor on the popular 1983 film "Flashdance" and the 1985 dance movie "White Nights."

The Times reported that, although some media sources had said he was 72, public records and his family confirmed that Ramone was 79.

Ramone was not associated with the punk band The Ramones, whose members all adopted pseudonyms using the surname Ramone.

(Reporting by Alex Dobuzinskis; Editing by Tim Gaynor and Philip Barbara)

Source: http://news.yahoo.com/versatile-music-producer-phil-ramone-dies-79-report-234022565.html

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White House takes North Korea's threats seriously

(AP) ? The White House said Saturday it is taking seriously new threats by North Korea but also noted Pyongyang's history of "bellicose rhetoric."

North Korea warned Seoul on Saturday that the Korean Peninsula had entered "a state of war." It also threatened to shut down a border factory complex that is the last major symbol of cooperation between the Koreas.

"We've seen reports of a new and unconstructive statement from North Korea. We take these threats seriously and remain in close contact with our South Korean allies," said Caitlin Hayden, a spokeswoman for the White House National Security Council. "But, we would also note that North Korea has a long history of bellicose rhetoric and threats, and today's announcement follows that familiar pattern."

North Korea's threats are seen as part of an effort to provoke the new government in Seoul to change its policies toward Pyongyang, and to win diplomatic talks with Washington that could get it more aid. The moves also are seen as ways to build domestic unity as North Korea's young leader, Kim Jong Un, strengthens his military credentials.

In recent days, the U.S. flew a pair of nuclear-capable B-2 stealth bombers over an uninhabited South Korean island, dropping dummy munitions as part of annual defense drills that North Korea views as rehearsals for an invasion. Defense Secretary Chuck Hagel also announced that the U.S. will fortify its defenses against a potential North Korean missile attack on the U.S. by adding more than a dozen missile interceptors to the 26 already in place at Fort Greely, Alaska.

North Korea said in a statement Saturday that it would deal with South Korea according to "wartime regulations" and would retaliate against any provocations by the U.S. and South Korea without notice.

"Now that the revolutionary armed forces of the DPRK have entered into an actual military action, the inter-Korean relations have naturally entered the state of war," said the statement, which was carried by the official North Korean news agency and referred to the country by its official name, the Democratic People's Republic of Korea.

Provocations "will not be limited to a local war, but develop into an all-out war, a nuclear war," the statement said.

The White House has stressed the U.S. government's capability and willingness to defend itself and its allies and interests in the region, if necessary.

"We remain fully prepared and capable of defending and protecting the United States and our allies," Hayden said.

___

Follow Darlene Superville on Twitter: http://www.twitter.com/dsupervilleap

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-30-US-Koreas-Tension-White-House/id-a73573bc8dd448c8badbdf8fa51e7686

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Caroline Kennedy returns to poetry for 10th book

In this Tuesday, March 26, 2013 photo, Caroline Kennedy flips through her new book "Poems to Learn by Heart" during an interview with The Associated Press in New York. Kennedy's 10th and latest book extols the value of learning poems by heart. (AP Photo/Mary Altaffer)

In this Tuesday, March 26, 2013 photo, Caroline Kennedy flips through her new book "Poems to Learn by Heart" during an interview with The Associated Press in New York. Kennedy's 10th and latest book extols the value of learning poems by heart. (AP Photo/Mary Altaffer)

In this Tuesday, March 26, 2013 photo, Caroline Kennedy speaks during an interview with The Associated Press in New York. Kennedy's 10th and latest book extols the value of learning poems by heart. (AP Photo/Mary Altaffer)

In this Tuesday, March 26, 2013 photo, copies of Caroline Kennedy's new book "Poems to Learn by Heart" sit on display during an interview with The Associated Press in New York. (AP Photo/Mary Altaffer)

In this Tuesday, March 26, 2013 photo, Caroline Kennedy smiles during an interview with The Associated Press in New York. Kennedy's 10th and latest book extols the value of learning poems by heart. (AP Photo/Mary Altaffer)

(AP) ? Beginning work a few years ago on her latest book, an anthology of poems for young people, Caroline Kennedy found herself looking through one of her mother's scrapbooks. She burst into laughter, she says, as she came across a poem that her brother John, as a youngster, had picked out and copied as a gift to their poetry-loving mom.

"Willie with a thirst for gore, Nailed his sister to the door," went the poem, by an unknown author. "Mother said with humor quaint, 'Careful, Willie, don't scratch the paint!'"

The poem "brought back memories of our relationship," Kennedy told a bookstore audience this week. "I laughed so hard."

But for Kennedy, now 55 and a mother of three grown children, there's a deeper meaning to that irreverent ditty. Poetry was a central part of her home life growing up. She and John regularly copied out and illustrated poems for their mother, Jackie, upon birthdays and Mother's Days. Sometimes, they'd recite them too, "if we were feeling competitive." And at family gatherings with their grandmother, there were frequent challenges to recite Henry Wadsworth Longfellow's famous (and famously lengthy) "Paul Revere's Ride." Only Uncle Ted, it seems, was able to recite it in its entirety.

Now, with her 10th book, Kennedy wants to share with young readers the love for the written word that she feels her poetry-filled childhood helped instill in her (even though her own son, she quips, hates reading and only likes two poems.) Hence the title: "Poems to Learn By Heart."

"It was a combination of remembering my own childhood and thinking about gifts I'd been given," she said in an interview last week at her husband's downtown Manhattan design firm, explaining the genesis of the latest book. "And working in schools and seeing the role that poetry can play in kids' lives."

It's also an effort to promote literacy, a cause Kennedy has supported in a number of ways. "Fourteen percent of American adults can't read," Kennedy says. "It's a slow-motion disaster." She believes poetry can help. "Kids need a way in," she says, "and reading needs to be fun. Poetry can give them that ? with the current emphasis on poetry slams, and these other open mic events. That's actually why I think poetry has a chance."

Kennedy's current book ? a collection of poems from various authors, with introductions by her to each section, and vivid illustrations by John J Muth ? is her fourth to focus on poetry. Her earlier books, especially "The Best Loved Poems of Jacqueline Kennedy Onassis," have been huge sellers, pulling in numbers unheard of for poetry anthologies.

"She's committed to becoming an advocate for the written word and poetry in particular," says Gretchen Young, who edited all of Kennedy's poetry books at Hyperion, working with the author to cull down huge numbers of beloved poems. "And she knows she can do that."

As to what else Kennedy can do with her high profile ? and the unique and powerful celebrity status she's held since she was a little girl in the Kennedy White House ? that is a question that people never cease to ask. The latest rumor has her up for an ambassadorship, perhaps to Japan, perhaps to Canada. Asked about those rumors during a recent TV appearance, she responded with typical restraint: "I'd love to serve in any way." She added that she hadn't been asked yet, and her response is still "No comment."

But many expect Kennedy, who considered seeking an appointment to the Senate from New York in 2009 but then withdrew her name from contention amid a flurry of publicity, to take up some high-profile position in the near future. She was an important and avid supporter of President Barack Obama, both in the 2008 and the 2012 elections.

"I'm really glad he's president," she says now when asked how he's doing, giving him high marks particularly in the field of education. "He can't do all the things he'd like to. We have a lot of problems. That's why I want young people to get engaged."

For now, though, Kennedy is making her mark in different ways. She is president of the John F. Kennedy Library Association, and in May will present the Profile in Courage award to former Arizona congresswoman Gabrielle Giffords. She still participates in fundraising activities for the New York City public schools, and is joining Laura Bush and Lynda Bird Johnson Robb to help the Library of Congress promote literacy through a new awards program, along with other authors, publishers and scholars.

Another pet project: Libraries, which she says are still critical places for young people to learn analytical skills. She's the honorary chair of National Library Week next month. "I'm into things that are dying out," she quips, then adds that actually they're not: "My son goes to the library all the time (at college.) There's a lot more socializing at the library than you think."

And she hints that she'll be writing other books, though not on poetry. "I think I'm pretty much done with the poetry books," she says. "I haven't figured out the next thing yet."

In any case, her attention to poetry has been a boon for all poets, says Stephen Young, program director at the Poetry Foundation, based in Chicago. "Selling poetry is, for most poets, a challenge," Young says. "It certainly helps when someone like Caroline Kennedy, who has an earnest and genuine interest in poetry, puts together these anthologies."

And while many might think that in this world of tweets and texts, the art of poetry is slowly dying out, the truth is that it seems to be on the upswing among young people, Young says ? partly because of poetry slams and the like, but also due to the Internet. "People can read AND listen to poems on the Web," Young notes.

And clearly, kids like to recite out loud. Along with the National Endowment for the Arts, the poetry foundation sponsors Poetry Out Loud, a contest similar to the National Spelling Bee. In 2006, there were 40,000 participants. This year's contest, which will hold its finals in Washington, D.C., in April, has 375,000, Young says.

It all speaks, in his view, to the fact that "poems are meant to be shared." Kennedy says this too; In her book, along with more famous poems, she includes "Voices Rising," a collaborative poem by students on the "slam team" at DreamYard Prep, a Bronx school Kennedy became familiar with in her work with public schools. Those students contributed ideas to the book, and three of them recited their poem together at Kennedy's kickoff reading last week at Barnes & Noble in New York.

Speaking of young people, Kennedy asked each of her own three kids ? Rose and Tatiana, who have finished college, and Jack, who is still there ? to contribute a favorite poem to her new book. (Tatiana, the "bookworm" according to her mother, translated a poem from Ovid's Metamorphoses, from the original Latin.) But she herself has trouble picking her favorite.

Asked by an audience member at her book reading to do just that, though, she settled on "Don't Worry if Your Job is Small."

"Don't worry if your job is small, and your rewards are few," it says.

"Remember that the mighty oak, was once a nut like you."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-03-31-Caroline%20Kennedy-Book/id-3907e9b7e33c475d8edbc4577292c361

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